CV Biowissenschaft
Lectures, seminars
Peer reviewed
Book articles
Course photo gallery

Schlothauer T, Herter S, Koller CF, Grau-Richards S, Steinhart V, Spick C, Kubbies M, Klein C, Umaña P, Mössner E: Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions. Protein Eng Des Sel, 2016.


Lehmann C, Jobs G, Thomas M, Burtscher H, Kubbies M: Established breast cancer stem cell markers do not correlate with in vivo tumorigenicity of tumor-initiating cells. Int. J. Oncology 41:1932-1942, 2012.


Kobold U, Duelffer T, Dangl M, Escherich A, Kubbies M, Roeddiger R, Wright JA: Quantification of hepcidin-25 in human serum by isotope dilution micro-HPLC-tandem mass spectroscopy. Clin Chem 54(9):1584-1586, 2008.


Ivascu A, Kubbies M: Diversity of cell-mediated adhesions in breast cancer spheroids. Int J Oncology 31(6):1403-1413, 2007.


Kokhaei P, Abdalla AO, Hansson L, Mikaelsson E, Kubbies M, Haselbeck A, Jernberg-Wiklund H, Mellsted H, Oesterborg A: Expression of erythropoetin receptor and in vitro functional effects of epoetins in B-cell malignancies. Clin Cancer Res 13(12):3536-3544, 2007.


Ivascu A, Kubbies M: Rapid generation of single-tumor spheroids for high-throughput cell function and toxicity analysis. J Biomol Screening 11(8):922-932, 2006.


Diermeier S, Schmidt-Bruecken E, Kubbies M, Kunz-Schughart LA, Brockhoff G: Exposure to continuous bromodeoxyuridine (BrdU) differentially affects cell cycle progression of human breast and bladder cancer cell lines. Cell Proliferation 37(2):195-206, 2004.


Hoevel T, Macek R, Swisshelm K, Kubbies M: Reexpression of the TJ protein CLDN1 induces apoptosis in breast tumor spheroids. Int J Cancer 108(3):374-383, 2004.


Macek R, Swisshelm K, Kubbies M: Expression and function of tight junction associated molecules in human breast tumor cells is not affected by the Ras-MEK1 pathway. Cell Mol Biol (Noisy-le-grand) 49(1):1-11, 2003.


Hoevel T, Macek R, Mundigl O, Swisshelm K, Kubbies M: Expression and targeting of the tight junction protein CLDN1 in CLDN1-negative human breast tumor cells. J Cell Physiol 191(1): 60-68, 2002.


Kraemer F, White K, Kubbies M, Swisshelm K, Weber BH: Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer. Human Genet 107(3):249-256, 2000.


Hoevel T, Holz H, Kubbies M: Cisplatin-digoxigenin mRNA labeling for nonradioactive detection of mRNA hybridized onto nucleic acid cDNA arrays. Biotechniques 27(5):1064-1067, 1999.


Swisshelm K, Machl A, Planitzer S, Robertson R, Kubbies M, Hosier S: SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells is a member of an epithelial membrane protein superfamily. Gene 226(2):285-295, 1999.


Planitzer S, Machl A, Schindler D, Kubbies M: Small deletions in the regulatory 3'UTR of alpha-tropomyosin  identified via differential display technique. Molecular and Cellular Probes 12(1): 35-40, 1998.


Planitzer S, Machl A, Rueckels M, Kubbies M: Identification of a novel cDNA overexpressed in Fanconi anemia fibroblasts partially homologous to a putative L-3-phosphoserine-phosphatase. Gene 210(2):297-306, 1998.


Machl A, Planitzer S, Kubbies M:  A novel membrane bound surface marker for ex vivo Fanconi anemia gene therapy, Gene Therapy 4(4):339-346, 1997.


Machl A, Planitzer S, Kubbies M: l-NGFR receptor, a new flow cytometric tool for rapid cell cycle correlated gene therapy complementation studies in viable cells. Cytometry 29(4):371-374, 1997.


Planitzer S, Machl A, Kubbies M: Applicability of non-syngeneic cell models for screening of genes in monogenetic diseases via differential display technique. Electrophoresis 18(15): 2865-2870, 1997.


Schulz-Knappe, Mägert HJ, Dewald B, Meyer M, Cetin Y, Kubbies M, et al, HCC-1, a novel chemokine from human plasma. J Exp Med 183(1):295-299, 1996.


Kubbies M: Principles of proliferation analysis by flow cytometry. Virch Archiv International J Pathol 427:328-329, 1995.


Giese G, Wiegers W,  Kubbies M, Scherbath A, Traub P: Okadaic acid coinduces vimentin expression and cell cycle arrest in MPC11 mouse  plasmacytoma cells. J Cell Physiol 163(1): 145-154, 1995.


Weller E, Kubbies M, Nüsse M: Induction of cell cycle perturbations by the tear gas 2-chloro-benzylidene malonitrile in synchronously and asynchronously proliferating mammalian cells. Cytometry, 19(4):334-342, 1995.


Giese G, Kubbies M, Traub P: High resolution analysis of cell cycle correlated vimentin expression in asynchronously grown, TPA treated MPC11 cells by the novel flow cytometric multiparameter BrdU-Hoechst/PI and immunolabeling technique. J Cell Physiol 161(2):209-216, 1994.


Kreipe H, Heidebrecht HJ, Hansen S, Röhlk, W, Kubbies, M, Wacker HH, Tieman M, Radzun HJ, Pawaresch MR: A new proliferation associated nuclear antigen detectable in paraffin-embedded tissue by the monoclonal antibody Ki-S1. Am J Pathology 142(1):3-9,1993.


Stockinger H, Kubbies M, Rudolph R, Stern A, Kohnert U, Fischer S: Binding of recombinant variants of human tissue-type plasminogen activator (tPA) to human umbilical vein endothelial cells. Thrombosis Res 67(5):589-599, 1992.


Kubbies M: Flow cytometric DNA histogram analysis: non-stoichiometric fluorochrome binding and pseudoaneuploidy. J Pathology 167(4):413-419, 1992.


Van Bockstaele DR, Lardon F, Snoeck H, Peetermans ME, Kubbies M: BrdU/Hoechst-EB quenching technique for studying kinetics of hematopoesis. Blood 80(1):289-291, 1992.


Kubbies M: Alteration of cell cycle kinetics by reducing agents in human PBL´s from adult and aged donors. Cell Proliferation 25(3):157-168, 1992.


Giese G, Kubbies M, Traub P: Cell cycle dependent vimentin expression in elutriator synchronized, TPA treated MPC11 mouse plasmacytoma cells. Exp Cell Res 200(1):118-125, 1992.  


Goller B, Kubbies M: UV lasers for flow cytometric analysis: HeCd versus argon laser excitation. J Histochem Cytochem 40(4):451-456, 1992.


Kubbies M, Goller B, Van Bockstaele DR: Improved BrdU/Hoechst bivariate cell kinetic analysis by helium cadmium single laser excitation. Cytometry 13(7):782786, 1992.


Omerod M, Kubbies M: Cell cycle analysis of asynchronous cell populations by flow cytometry using bromodeoxyuridine label and Hoechst Propidium Iodide stain. Cytometry 13(7):678-685, 1992.


Kubbies M, Goller B, Schetters B, Bartosek I, Albert W: Glutathione restores normal cell activation and cell cycle progression in cisplatinum toxified human lymphocytes. Br J Cancer 64(5):843-849, 1991.


Lawtzky A, Kubbies M, Hünig T:  Rat "first wave" mature thymocytes: cycling lymphoblasts that are sensitive to activation induced cell death but rescued by IL2. Europ J Immunol 21(10):2599-2604, 1991.


Giese G, Kubbies M, Traub P: Alterations of cell kinetics and vimentin expression in TPA treated, asynchronous MPC11 mouse plasmacytoma cells. Exp Cell Res 190(2):179-184, 1990.  


Kubbies M, Stockinger H: Cell cycle dependent DHFR and tPA production in CHO-transfected, MTX amplified CHO cells revealed by dual laser flow cytometry. Exp Cell Res 188(2):267-271, 1990.


Kubbies M: Flow cytometric recognition of clastogen induced chromatin damage in G0/G1 lymphocytes by nonstoichiometric Hoechst fluorochrome binding. Cytometry 11(3):386-394, 1990.


Kubbies M, Friedl R, Koehler J, Rabinovitch PS, Hoehn H: Improvement  of human lymphocyte proliferation and alteration of IL2 secretion kinetics by alpha-thioglycerol. Lymphokine Research 9(1):95-106, 1990.


Kubbies M, Goller B, Russmann E, Stockinger H, Scheuer W: Complex Ca2+ flux inhibition as primary mechanism of staurosporine induced impairment of T-cell activation. Europ J Immunol 19(8):1393-1398, 1989.


Poot M, Schmitt H,  Seyschab H, Koehler J, Chen U, Kaempf U, Kubbies M, Schindler D, Rabinovitch PS, Hoehn H: Continous BrdU labeling and bivariate Ethidium bromide/Hoechst 33258 flow cytometry demonstrates mitogen response and cell cycle progression in primary and established human and murine cell cultures. Cytometry 10(2):222-226, 1989.


Schindler D, Kubbies M, Priest RE, Hoehn H, Rabinovitch PS: The phythemagglutinin response of human peripheral blood lymphocytes as a function of donor age: a reexamination using BrdU/Hoechst flow cytometry. Mech Ageing Develop 44(3):253-263, 1988.


Poot M, Schindler D, Kubbies M, Hoehn H, Rabinovitch PS: Bromodeoxyuridine amplifies the inhibitory effect of oxygen on cell proliferation. Cytometry 9(4):332-338, 1988.


Rabinovitch PS, Kubbies M, Chen YC, Schindler D, Hoehn H: BrdU/Hoechst flow cytometry: a unique tool for quantitative cell cycle analysis. Exp Cell Res 174(2):309-318, 1988.


Hoehn H, Koch H, Köhler J, Bettecken T, Kubbies M, Heckl W, Salk D,  Rabinovitch PS: Interphase flow cytometry as a means of monitoring genomic size in normal and neoplastic cell cultures. Cancer Genet Cytogenet 24(2):191-204, 1987.


Schindler D, Kubbies M, Hoehn H, Schinzel A, Rabinovitch PS: Confirmation of Fanconi Anemia and detection of a preleukemic abberation (1Q1232 triplication) via BrdU-Hoechst flow cytometry. Am J Pediat Hemat/Oncol 9(2):172-177, 1987.


Kubbies M, Hoehn H, Rabinovitch PS: Differences in growth factor sensitivity between primary and transformed murine cell cultures revealed by BrdU/Hoechst flow cytometry. Exp Cell Biol 55(5):225-236, 1987.


Heckl W, Friedl R, Kubbies M: Analysis of cell cycle distribution of human bladder cancer cells by BrdU/Hoechst flow cytometry. Invest Urology 2:24-28, 1987.


Kubbies M, Friedl R, Bettecken T, Hoehn H: The fate  of  the primary diploid population during spontaneous transformation of growth factor supplemented murine cell cultures. Cytometry 7:551-557, 1986.


Kubbies M,  Wick R, Hildebrandt A, Sauer HW: Flow cytometry reveals a high degree of genomic size variation and  mixoploidy in various strains of  the acellular slime mold Physarum polycephalum. Cytometry 7(5):481-485, 1986.


Kubbies M, Schindler D, Hoehn H, Rabinovitch PS: BrdU/Hoechst flow cytometry reveals regulation of human lymphocyte growth by donor age related growth fraction and transition rate. J Cell Physiol 125(2):229-234, 1985.


Kubbies M, Schindler D, Hoehn H, Schinzel A, Rabinovitch PS: Endogenous blockage and delay of the chromosome cycle despite normal recruitment and growth phase explain poor proliferation and frequent endomitosis in Fanconi Anemia cells. Am J Hum Genet 37(5):1022-1030, 1985.


Kubbies  M,  Schindler D,  Hoehn H, Rabinovitch PS: Cell cycle kinetics by BrdU-Hoechst flow cytometry: A powerful alternative to the differential metaphase labeling technique. Cell Tissue Kinet 18(5):551-562, 1985.


Schindler D, Kubbies M, Hoehn H, Schinzel A, Rabinovitch PS: Presymtomatic diagnosis of Fanconi's Anemia. Lancet 1(8434):937,1985.


Kubbies M,  Friedl R: Flow cytometric correlation between BrdU-Hoechst quench effect and base pair composition in mammalian cell nuclei. Histochemistry 83(2):133-137, 1985.


Koch H,  Bettecken T,  Kubbies M,  Salk D, Smith JW, Rabinovitch PS: Flow cytometric analysis of small DNA content differences in heterogenous cell populations: Human amniotic fluid cells. Cytometry 5(2):118-123, 1984.


Kubbies M,  Pierron G: Mitotic cell cycle control in Physarum: Unprecedented insights via flow cytometry.  Exp Cell Res 149(1):57-67, 1983.


Wolbert P, Kubbies M: The cell cycle of epidermal cells during reprogramming in the pupa of Galleria. J Insect Physiol 29(10):787-794, 1983.


Brachertz M, Kubbies M, Feige A, Salk D: Decreased oxygen supply enhances growth in culture of human midtrimester amniotic fluid cells. Hum Genet 64(4):334-338, 1983.


Kubbies M, Rabinovitch PS: Flow cytometric analysis of factors which influence the BrdU-Hoechst quenching effect in cultivated human fibroblasts and lymphocytes. Cytometry 3(4):276-281, 1983.